The Bristol & Oxford Chemical Dynamics Group

Mass resolved microscopy by multi-mass imaging

Mass resolved microscopy is a powerful analytical technique which produces a chemical map of a surface using mass spectrometric techniques. There are a variety of ways by which this can be achieved and the technology in this field is constantly being improved. Work in the Programme Grant is intended to continue development of a stigmatic mass microscope using the Pixel Imaging Mass Spectrometry (PImMS) camera in producing a high resolution, parallel mass analysis technique. The PImMS camera allows images associated with multiple ion masses to be acquired simultaneously from a single laser shot.

Two images of dyes with different masses, and spatial distributions. Both of these were obtained simultaneously.

A mass spectrum of a polyethylene glycol polymer obtained using the PImMS camera and an adapted commercial mass spectrometer. Each peak in the spectrum has an associated image.

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